Body mass index correlates with atherogenic lipoprotein profile even in nonobese, normoglycemic, and normolipidemic healthy men

Montse Guardiola (1) , Rosa Solà (1) , Joan Carles Vallvé (1) , Josefa Girona (1) , Gemma Godàs (1) , Mercedes Heras (1) , Marta Gonzàlez (1) , Edmond Rock (2) , Brigitte M Winklhoffer-Roob (3) , Lluís Masana (4, 5) , Josep Ribalta (1)

1 Facultat de Medicina, Departament de Medicina i Cirurgia, Unitat de Recerca en Lípids i Arteriosclerosi
2 UNH - Unité de Nutrition Humaine
3 Human Nutrition and Metabolism Research and Training Center, Institute of Molecular Biosciences
4 Facultat de Medicina, Departament de Medicina i Cirurgia, Unitat de Recerca en Lípids i Arteriosclerosi
5 IISPV - Institut d'Investigació Sanitària Pere Virgili [Tarragona]

To establish a relationship between body mass index (BMI), lipid, and lipoprotein parameters among nonobese, normoglycemic, and normolipidemic healthy men without any cardiovascular, metabolic, or chronic diseases.[br/] A total of 297 healthy, nonsmoking males between 20 and 75 years were recruited. Exclusion criteria included familial hypercholesterolemia, any chronic diseases, and BMI ≥ 30 kg/m(2). Lipid and lipoprotein particles were determined by standard methods, with the use of ultracentrifugation and nuclear magnetic resonance (NMR). Cholesterol in remnant-like particles (RLPc) was also determined.[br/] These healthy volunteers were separated into two groups: normoweight (BMI > 19 kg/m(2) and <25 kg/m(2) [n = 143]) and overweight (BMI ≥ 25 kg/m(2) and <30 kg/m(2) [n = 154]). Overweight participants were older (P < .001) compared to normoweight. Both groups had low-density lipoprotein (LDL) cholesterol levels (<130 mg/dL) considered as desirable, and although both groups had plasma triglyceride levels within the nonpathological range, overweight participants presented with 30% higher triglyceride levels (P < .001) and 9% lower high-density lipoprotein cholesterol (P < .001) compared to normoweight individuals. Although LDL was comparable between groups, NMR analysis showed that overweight participants had 27% more total LDL particles due to a 16% decrease in large LDL (P < .001) and 70% increase in the smaller subclasses (P < .001). In overweight participants, NMR analysis also showed a 2-fold increase in large very low-density lipoprotein (P = .001), and 30% more medium very low-density lipoprotein particles (P = .020). Overweight participants also had 70% more intermediate-density lipoprotein particles (P = .010), a 30% decrease in large high-density lipoprotein particles (P < .001), and a 39% increase in RLPc levels (P = .005). Results were adjusted for age and fat intake.[br/] BMI correlates with a shift toward a more proatherogenic lipoprotein profile even in individuals whose lipid levels were not elevated.

Mots clés: Atherogenic dyslipidemia; BMI; Healthy participants; Lipoprotein; NMR

Domaines: Alimentation et Nutrition

Montse Guardiola, Rosa Solà, Joan Carles Vallvé, Josefa Girona, Gemma Godàs, et al.. Body mass index correlates with atherogenic lipoprotein profile even in nonobese, normoglycemic, and normolipidemic healthy men. Journal of clinical lipidology, 2015, 9 (6), pp.824-831. ⟨10.1016/j.jacl.2015.08.001⟩. ⟨hal-01281830⟩