Synthesis of 5-Substituted 1,2,3-Triazolyl-4-phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-phosphonate

Emilie Thiery (1) , Vanny You (2) , Anne-Sophie Mora (2) , Mohamed Abarbri (1)

1 UMR ISP - Infectiologie et Santé Publique
2 Université Francois Rabelais [Tours]

Two methods for the preparation of 5-iodo-1,2,3-triazolyl-4-phosphonate were explored. This compound was then functionalized by Suzuki and Stille cross-coupling reaction to obtain 5-aryl-, 5-heteroaryl- or 5-alkenyl-1,2,3-triazolyl-4-phosphonates.

Mots clés: Cross-coupling; Nitrogen heterocycles; Synthetic methods; Click chemistry; Cycloaddition

Domaines: Autre

Emilie Thiery, Vanny You, Anne-Sophie Mora, Mohamed Abarbri. Synthesis of 5-Substituted 1,2,3-Triazolyl-4-phosphonate through Cross-Coupling Reactions of 5-Iodo-1,2,3-triazolyl-4-phosphonate. European Journal of Organic Chemistry, 2016, 2016 (3), pp.529-534. ⟨10.1002/ejoc.201501266⟩. ⟨hal-01276734⟩