Impact of acoustic airflow on intrasinus drug deposition: New insights into the vibrating mode and the optimal acoustic frequency to enhance the delivery of nebulized antibiotic

Lara Leclerc (1) , Amira El Merhie (1) , Laurent Navarro (1) , Nathalie Prévôt (1, 2) , Marc Durand (3, 1) , Jérémie Pourchez (1)

1 LINA-ENSMSE - Laboratoire Interdisciplinaire d'Etude des Nanoparticules Aérosolisées
2 CHU ST-E - Centre Hospitalier Universitaire de Saint-Etienne [CHU Saint-Etienne]
3 Centre Hospitalier Emile Roux [AP-HP]

Aim: We investigated the impact of vibrating acoustic airflow, the high frequency (f ≥ 100 Hz) and the low frequency (f ≤ 45 Hz) sound waves, on the enhancement of intrasinus drug deposition. Methods: 81mKr-gas ventilation study was performed in a plastinated human cast with and without the addition of vibrating acoustic airflow. Similarly, intrasinus drug deposition in a nasal replica using gentamicin as a marker was studied with and without the superposition of different modes of acoustic airflow. Results: Ventilation experiments demonstrate that no sinus ventilation was observed without acoustic airflow although sinus ventilation occurred whatever the modes of acoustic airflow applied. Intrasinus drug deposition experiments showed that the high frequency acoustic airflow led to 4-fold increase in gentamicin deposition into the left maxillary sinus and to 2-fold deposition increase into the right maxillary sinus. Besides, the low frequency acoustic airflow demonstrated a significant increase of 4-fold and 2-fold in the right and left maxillary sinuses respectively. Conclusion: We demonstrated the benefit of different modes of vibrating acoustic airflow for maxillary sinus ventilation and intrasinus drug deposition. The degree of gentamicin deposition varies as a function of frequency of the vibrating acoustic airflow and the geometry of the ostia.

Mots clés: vibrating acoustic airflow; high frequency; low frequency; intrasinus deposition; 81mKr-gas ventilation.

Domaines: Génie des procédés

Lara Leclerc, Amira El Merhie, Laurent Navarro, Nathalie Prévôt, Marc Durand, et al.. Impact of acoustic airflow on intrasinus drug deposition: New insights into the vibrating mode and the optimal acoustic frequency to enhance the delivery of nebulized antibiotic. International Journal of Pharmaceutics, 2015, 494 (1), pp.227-234. ⟨10.1016/j.ijpharm.2015.08.025⟩. ⟨hal-01272228⟩