Impact of eNOS polymorphisms on red blood cell aggregation in sickle cell disease

Séverine Ferdinand (1) , Philippe Connes (2) , Laura Brudey (1) , Kizzy-Clara Cita (1) , Benoit Tressières (3) , Nathalie Lemonne (4) , Marie-Dominique Hardy-Dessources (5) , Yann Lamarre (5) , Xaxier Waltz (2) , Maryse Etienne-Julan (4) , Marc Romana (5)

1 Observatoire Régional de la Santé de la Guadeloupe
2 UAG - Université des Antilles et de la Guyane
3 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
4 CHU Pointe-à-Pitre/Abymes [Guadeloupe]
5 Protéines de la membrane érythrocytaire et homologues non-érythroides

Hemorheological abnormalities have been well characterized in sickle cell disease (SCD) and seem to modulate the clinical severity [1]. For instance, increased blood viscosity raises the risk for frequent vaso-occlusive crisis (VOC) and increased red blood cell (RBC) aggregates robustness (i.e., RBC disaggregation threshold) enhances the risks for acute chest syndrome (ACS) [2]. Moreover, patients with the most rigid RBCs are characterized by high hemolytic rate, which increases the risks to develop leg ulcers or glomerulopathy [3]. However, except few studies supporting an effect of alpha-thalassemia and oxidative stress [1] on RBC rheological properties of SCD patients, very few experiments focused on the genetic and cellular factors modulating blood rheology in this disease.

Domaines: Santé publique et épidémiologie

Séverine Ferdinand, Philippe Connes, Laura Brudey, Kizzy-Clara Cita, Benoit Tressières, et al.. Impact of eNOS polymorphisms on red blood cell aggregation in sickle cell disease. Blood Cells, Molecules and Diseases, 2015, 55 (2), pp.151-3. ⟨hal-01263890⟩