A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk

I. Tramacere , C. Pelucchi , V. Bagnardi , M. Rota , L. Scotti , F. Islami , G. Corrao , P. Boffetta (1, 2) , C. La Vecchia (1) , E. Negri

1 IPRI - International Prevention Research Institute
2 The Tisch Cancer Institute

BACKGROUND: In order to provide a precise quantification of the association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, we conducted a meta-analysis of available data. PATIENTS AND METHODS: We identified 20 case-control and 4 cohort studies, including a total of 5500 cases. We derived meta-analytic estimates using random-effects models, taking into account correlation between estimates, and we carried out a dose-risk analysis using nonlinear random-effects meta-regression models. RESULTS: The relative risk (RR) for drinkers versus nondrinkers was 0.96 [95% confidence interval (CI) 0.85-1.09] overall, 0.87 (95% CI 0.74-1.01) for esophageal adenocarcinoma and 0.89 (95% CI 0.76-1.03) for gastric cardia adenocarcinoma. Compared with nondrinkers, the pooled RRs were 0.86 for light (/= 4 drinks per day) alcohol drinking. The dose-risk model found a minimum at 25 g/day, and the curve was < 1 up to 70 g/day. CONCLUSIONS: This meta-analysis provides definite evidence of an absence of association between alcohol drinking and esophageal and gastric cardia adenocarcinoma risk, even at higher doses of consumption.

Mots clés: Adenocarcinoma/*epidemiology/etiology Alcohol Drinking/*adverse effects/epidemiology Cardia Case-Control Studies Cohort Studies Esophageal Neoplasms/*epidemiology/etiology Female Humans Male Regression Analysis Risk Stomach Neoplasms/*epidemiology/etiology

Domaines: Santé publique et épidémiologie

I. Tramacere, C. Pelucchi, V. Bagnardi, M. Rota, L. Scotti, et al.. A meta-analysis on alcohol drinking and esophageal and gastric cardia adenocarcinoma risk. Annals of Oncology, 2012, 23 (2), pp.287-97. ⟨10.1093/annonc/mdr136⟩. ⟨hal-01262939⟩