Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

A. Wyss , M. Hashibe , S. C. Chuang , Y. C. Lee , Z. F. Zhang , G. P. Yu , D. M. Winn , Q. Wei , R. Talamini , N. Szeszenia-Dabrowska , E. M. Sturgis , E. Smith , O. Shangina , S. M. Schwartz , S. Schantz , P. Rudnai , M. P. Purdue , J. Eluf-Neto , J. Muscat , H. Morgenstern , Jr. Michaluart , A. Menezes , E. Matos , I. N. Mates , J. Lissowska , F. Levi , P. Lazarus , C. La Vecchia , S. Koifman , R. Herrero , R. B. Hayes , Sophie Franceschi-Messant , V. Wunsch-Filho , L. Fernandez , E. Fabianova , A. W. Daudt , L. Dal Maso , M. P. Curado (1) , C. Chen , X. Castellsague , M. B. De Carvalho , G. Cadoni , S. Boccia , P. Brennan , P. Boffetta (1, 2) , A. F. Olshan

1 IPRI - International Prevention Research Institute
2 The Tisch Cancer Institute

Cigar and pipe smoking are considered risk factors for head and neck cancers, but the magnitude of effect estimates for these products has been imprecisely estimated. By using pooled data from the International Head and Neck Cancer Epidemiology (INHANCE) Consortium (comprising 13,935 cases and 18,691 controls in 19 studies from 1981 to 2007), we applied hierarchical logistic regression to more precisely estimate odds ratios and 95% confidence intervals for cigarette, cigar, and pipe smoking separately, compared with reference groups of those who had never smoked each single product. Odds ratios for cigar and pipe smoking were stratified by ever cigarette smoking. We also considered effect estimates of smoking a single product exclusively versus never having smoked any product (reference group). Among never cigarette smokers, the odds ratio for ever cigar smoking was 2.54 (95% confidence interval (CI): 1.93, 3.34), and the odds ratio for ever pipe smoking was 2.08 (95% CI: 1.55, 2.81). These odds ratios increased with increasing frequency and duration of smoking (Ptrend

Mots clés: Adolescent Adult Age Distribution Aged Aged; 80 and over Female Head and Neck Neoplasms/*epidemiology Humans Male Middle Aged Odds Ratio Risk Factors Sex Distribution Smoking/*epidemiology Socioeconomic Factors Young Adult

Domaines: Santé publique et épidémiologie

A. Wyss, M. Hashibe, S. C. Chuang, Y. C. Lee, Z. F. Zhang, et al.. Cigarette, cigar, and pipe smoking and the risk of head and neck cancers: pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Am J Epidemiol, 2013, 178 (5), pp.679-90. ⟨10.1093/aje/kwt029⟩. ⟨hal-01261751⟩