Intramolecular amidoalkylation cyclizations in synthesis of novel pyrrolo(or isoindolo)thieno[2]benzazepines

Aïcha Mamouni (1) , Pascal Pigeon (1) , Abdel Adam Daïch (1) , Bernard Decroix (1)

1 ULH - Université Le Havre Normandie

Thieno[2]benzazepines annulated to pyrrole 8a,b or isoindole 8c have been synthesized utilizing the acid-catalyzed cyclization of hydroxylactams 7a-c as key step.

Domaines: Chimie organique; Chimie thérapeutique

Aïcha Mamouni, Pascal Pigeon, Abdel Adam Daïch, Bernard Decroix. Intramolecular amidoalkylation cyclizations in synthesis of novel pyrrolo(or isoindolo)thieno[2]benzazepines. Journal of Heterocyclic Chemistry, 1997, 34 (5), pp.1495-1499. ⟨10.1002/jhet.5570340519⟩. ⟨hal-01230424⟩