The SPI-1-like Type III secretion system: more roles than you think

Frank Egan (1) , Matthieu Barret (2) , Fergal O'Gara (3, 1)

1 BIOMERIT Research Centre, School of Microbiology
2 IRHS - Institut de Recherche en Horticulture et Semences
3 School of Biomedical Science

The type III secretion system (T3SS) is a protein delivery system which is involved in a wide spectrum of interactions, from mutualism to pathogenesis, between Gram negative bacteria and various eukaryotes, including plants, fungi, protozoa and mammals. Various phylogenetic families of the T3SS have been described, including the Salmonella Pathogenicity Island 1 family (SPI-1). The SPI-1 T3SS was initially associated with the virulence of enteric pathogens, but is actually found in a diverse array of bacterial species, where it can play roles in processes as different as symbiotic interactions with insects and colonization of plants. We review the multiple roles of the SPI-1 T3SS and discuss both how these discoveries are changing our perception of the SPI-1 family and what impacts this has on our understanding of the specialization of the T3SS in general.

Mots clés: SPI-1; T3SS; phytopathogens; Salmonella; insect; amoeba; E3 UBIQUITIN LIGASE; PV. TOMATO DC3000; SALMONELLA-TYPHIMURIUM; CELL-DEATH; MOLECULAR CHARACTERIZATION; SACCHAROMYCES-CEREVISIAE; ARABIDOPSIS-THALIANA; INNATE IMMUNITY; HOST-CELLS; PLANT

Domaines: Sciences du Vivant [q-bio]

Frank Egan, Matthieu Barret, Fergal O'Gara. The SPI-1-like Type III secretion system: more roles than you think. Frontiers in Plant Science, 2014, 5, ⟨10.3389/fpls.2014.00034⟩. ⟨hal-01210004⟩