Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs

Michael Baco (1, 2) , Chia-Ying Chu (3, 4) , Stephan Bouet (1, 2) , Claire Gaillard (1) , Emmanuelle Bourneuf (1, 2) , Fabienne Le Provost (1) , Chia-Yu Chu (4, 5) , Silvia Vincent-Naulleau (1, 2)

1 GABI - Génétique Animale et Biologie Intégrative
2 CEA, DSV, IRCM, SREIT, Laboratoire de Radiobiologie et d'Etude du génome
3 Institute of Zoology, College of Life Science
4 Center for Systems Biology
5 Department of Dermatology, National Taiwan University Hospital and National Taiwan University College of Medicine

Treatment of advanced cutaneous melanoma is still challenging and new data on melanoma biology are required. MicroRNAs (miRNAs) represent an emerging field in melanoma understanding. These small regulators of gene expression, involved in melanoma development and progression (Da cruz et al., 2012), showed promising results as biomarkers (Nair et al., 2012). As each miRNA could regulate multiple protein-coding genes and conversely, one gene could be targeted by different miRNAs (Bartel et al., 2009), the dysregulation of miRNAs could significantly impact various pathways and cells behavior.

Domaines: Sciences du Vivant [q-bio]

Michael Baco, Chia-Ying Chu, Stephan Bouet, Claire Gaillard, Emmanuelle Bourneuf, et al.. Analysis of melanoma-related microRNAs expression during the spontaneous regression of cutaneous melanomas in MeLiM pigs. Pigment Cell and Melanoma Research, 2014, 27 (4), pp.668-670. ⟨10.1111/pcmr.12243⟩. ⟨hal-01193803⟩