Cartographie fine de régions QTL à l’aide de la puce PorcineSNP60 pour la qualité de la viande en race Large White

Marie-Pierre Sanchez (1) , Thierry Tribout (1) , Nathalie Iannuccelli (2) , Marcel Bouffaud (3) , Bertrand Servin (2) , Patrice Dehais (2) , Nelly Muller (3) , Marie-José Mercat (4) , Jordi Estellé (1) , Jean Pierre Bidanel (1) , Claire Gaillard (1) , Denis Milan (2) , Hélène Gilbert (2)

1 GABI - Génétique Animale et Biologie Intégrative
2 LGC - Laboratoire de Génétique Cellulaire
3 Unité expérimentale de testage de porcs
4 Pôle génétique

A total of 389 French Large White pigs (106 sire families) were controlled for ultimate pH of [i]semimembranosus[/i] muscle, L* a* b* Minolta values and water holding capacity of [i]gluteus superficialis[/i] muscle, and a meat quality index was computed. Pigs were genotyped using the [i]PorcineSNP60[/i] Beadchip containing 64,432 SNP (Single Nucleotide Polymorphism) markers. A genome-wide association study (GWAS) was then performed with the FASTA method. Thirty-three significant SNP effects (P<10-4) were identified on chromosomes (SSC) 1, 3, 4, 7, 8, 9, 13 and 14. Further haplotypic analyses revealed a 6-SNP region (183kb) on SSC1 with 3 major haplotypes having favourable (ACTCTA, 57%), intermediate (GTCTCC, 19%) and unfavourable (ACTTTC, 24%) effects on meat quality. Complementary analyses showed that these haplotypes did not affect growth rate or body composition of the pigs. Further investigations are required but these results are of potential interest to improve technological meat quality.

Domaines: Sciences du Vivant [q-bio]

Marie-Pierre Sanchez, Thierry Tribout, Nathalie Iannuccelli, Marcel Bouffaud, Bertrand Servin, et al.. Cartographie fine de régions QTL à l’aide de la puce PorcineSNP60 pour la qualité de la viande en race Large White. Journées des Sciences du muscle et technologie de la viansde, Nov 2012, Caen, France. ⟨hal-01190243⟩