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Integrating Multimodal Priors in Predictive Models for the Functional Characterization of Alzheimer's Disease

Abstract : Functional brain imaging provides key information to characterize neurodegenerative diseases, such as Alzheimer's disease (AD). Specifically, the metabolic activity measured through fluorodeoxyglu-cose positron emission tomography (FDG-PET) and the connectivity extracted from resting-state functional magnetic resonance imaging (fMRI), are promising biomarkers that can be used for early assessment and prognosis of the disease and to understand its mechanisms. FDG-PET is the best suited functional marker so far, as it gives a reliable quantitative measure, but is invasive. On the other hand, non-invasive fMRI acquisitions do not provide a straightforward quantification of brain functional activity. To analyze populations solely based on resting-state fMRI, we propose an approach that leverages a metabolic prior learned from FDG-PET. More formally, our classification framework embeds population priors learned from another modality at the voxel-level, which can be seen as a regularization term in the analysis. Experimental results show that our PET-informed approach increases classification accuracy compared to pure fMRI approaches and highlights regions known to be impacted by the disease.
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https://hal.archives-ouvertes.fr/hal-01174636
Contributor : Mehdi Rahim <>
Submitted on : Thursday, July 9, 2015 - 2:01:22 PM
Last modification on : Monday, February 10, 2020 - 6:13:43 PM
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Mehdi Rahim, Bertrand Thirion, Alexandre Abraham, Michael Eickenberg, Elvis Dohmatob, et al.. Integrating Multimodal Priors in Predictive Models for the Functional Characterization of Alzheimer's Disease. Medical Image Computing and Computer Assisted Intervention, Oct 2015, Munich, Germany. ⟨10.1007/978-3-319-24553-9_26⟩. ⟨hal-01174636⟩

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