Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation

Danitza Nebor (1) , Andre Bowers (2) , Marie-Dominique Hardy-Dessources (1) , Jennifer Knight-Madden (3) , Marc Romana (1) , Harvey Reid (2) , Jean-Claude Barthélémy (4) , Vanessa Cumming (3) , Olivier Hue (5) , Jacques Elion (1) , Marvin Reid (3) , Philippe Connes (1, 5)

1 Inserm U763, Pointe-à-Pitre, Guadeloupe; Université des Antilles et de la Guyane
2 Department of Basic Medical Sciences (Physiology Section), Faculty of Medical Sciences
3 Sickle Cell Unit, Tropical Medicine Research Institute
4 SNA - EPIS - Système Nerveux Autonome - Epidémiologie, Physiologie, Ingénierie, Santé
5 ACTES - Adaptations au Climat Tropical, Exercice et Santé

Background Recent evidence suggests that autonomic nervous system activity could be involved in the pathophysiology of sickle cell disease, but it is unclear whether differences in autonomic nervous system activity are detectable during steady state in patients with mild and severe disease. The aim of the present study was to compare the autonomic nervous system activity, blood rheology, and inflammation in patients with sickle cell anemia according to the frequency of acute pain crisis. Design and Methods Twenty-four healthy volunteers, 20 patients with sickle cell anemia with milder disease, and 15 patients with sickle cell anemia with more severe disease were recruited. Milder disease was defined as having no pain crisis within the previous year. More severe disease was defined as having had within the previous year three or more pain crises which were documented by a physician and required treatment with narcotics. The autonomic nervous system activity was determined by spectral analysis of nocturnal heart rate variability. Blood viscosity determination and measurements of several inflammatory markers (interleukin-6, soluble vascular cell adhesion molecule-1, soluble CD40 ligand and sL-selectin) were made on blood samples collected in steady-state conditions. Results Results showed that: 1) patients who had suffered more frequent pain crises had lower parasympathetic activity and greater sympatho-vagal imbalance than both controls and patients with milder disease. However, when adjusted for age, no significant difference was detected between the two sickle cell anemia patient groups; 2) patients who had suffered more frequent pain crises had higher blood viscosity than patients with milder disease, and this was not dependent on age. Conclusions Results from the present study indicate that both the autonomic nervous system activity and blood viscosity are impaired in patients with sickle cell anemia exhibiting high frequency of pain crisis in comparison with those who did not experience a crisis within the previous year.

Mots clés: sickle cell anemia; autonomic function; inflammation; hemoglobin; blood viscosity

Domaines: Sciences du Vivant [q-bio]

Danitza Nebor, Andre Bowers, Marie-Dominique Hardy-Dessources, Jennifer Knight-Madden, Marc Romana, et al.. Frequency of pain crises in sickle cell anemia and its relationship with the sympatho-vagal balance, blood viscosity and inflammation. Haematologica, 2011, 96 (11), pp.1589-1594. ⟨10.3324/haematol.2011.047365⟩. ⟨hal-01163973⟩