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A novel tool for the prediction of transmembrane protein topology based on a statistical analysis of the SwissProt database: the OrienTM algorithm

Abstract : OrienTM is a computer software that utilizes an initial definition of transmembrane segments to predict the topology of transmembrane proteins from their sequence. It uses position-specific statistical information for amino acid residues which belong to putative non-transmembrane segments derived from statistical analysis of non-transmembrane regions of membrane proteins stored in the SwissProt database. Its accuracy compares well with that of other popular existing methods. A web-based version of OrienTM is publicly available at the address http://biophysics.biol.uoa.gr/OrienTM.
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https://hal.archives-ouvertes.fr/hal-01154852
Contributor : Claude Pasquier <>
Submitted on : Monday, November 16, 2020 - 7:29:51 AM
Last modification on : Friday, November 20, 2020 - 10:11:52 AM

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  • HAL Id : hal-01154852, version 1
  • PUBMED : 11477216

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T D Liakopoulos, Claude Pasquier, S J Hamodrakas. A novel tool for the prediction of transmembrane protein topology based on a statistical analysis of the SwissProt database: the OrienTM algorithm. Protein Engineering, 2001, 14 (6), pp.387-90. ⟨hal-01154852⟩

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