A novel tool for the prediction of transmembrane protein topology based on a statistical analysis of the SwissProt database: the OrienTM algorithm

T D Liakopoulos (1) , Claude Pasquier (1) , S J Hamodrakas (1)

1 NKUA - National and Kapodistrian University of Athens

OrienTM is a computer software that utilizes an initial definition of transmembrane segments to predict the topology of transmembrane proteins from their sequence. It uses position-specific statistical information for amino acid residues which belong to putative non-transmembrane segments derived from statistical analysis of non-transmembrane regions of membrane proteins stored in the SwissProt database. Its accuracy compares well with that of other popular existing methods. A web-based version of OrienTM is publicly available at the address http://biophysics.biol.uoa.gr/OrienTM.

Mots clés: Protein structure prediction

Domaines: Bio-informatique [q-bio.QM]

T D Liakopoulos, Claude Pasquier, S J Hamodrakas. A novel tool for the prediction of transmembrane protein topology based on a statistical analysis of the SwissProt database: the OrienTM algorithm. Protein Engineering, 2001, 14 (6), pp.387-90. ⟨hal-01154852⟩