Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands

F. Guillen (1) , Caroline L. Winn (1) , Alexandre Alexakis (1)

1 Département de Chimie Organique

Chiral diaminocarbene ligands, generated by in-situ deprotonation of the corresponding chiral imidazolinium salts, are shown to be efficient ligands in the asymmetric copper-catalyzed 1,4-conjugate addition of diethylzinc to enones, allowing enantiomeric excesses of up to 51% to be achieved.

Domaines: Chimie organique

F. Guillen, Caroline L. Winn, Alexandre Alexakis. Enantioselective copper-catalyzed conjugate addition using chiral diaminocarbene ligands. Tetrahedron: Asymmetry, 2001, 12 (15), pp.2083. ⟨10.1016/S0957-4166(01)00387-1⟩. ⟨hal-01146973⟩