Inhibition of the NF-kappa B Pathway in Human Intestinal Epithelial Cells by Commensal Streptococcus salivarius

Ghalia G. Kaci (1) , Omar O. Lakhdari (1) , Joel J. Dore (1) , Stanislav S. Ehrlich (1) , Pierre Renault (1) , Herve H. Blottiere (1) , Christine C. Delorme (1)

1 MICALIS - MICrobiologie de l'ALImentation au Service de la Santé

Streptococcus salivarius exhibited an anti-inflammatory effect on intestinal epithelial cells (IECs) and monocytes. Strains were screened using a reporter clone, HT-29/kB-luc-E, induced by tumor necrosis factor alpha (TNF-alpha). Supernatant from each strain downregulated NF-kappa B activation. The two most efficient strains produced an active metabolite (<3 kDa) which was able to downregulate the secretion of the proinflammatory chemokine interleukin-8 (IL-8).

Mots clés: INFLAMMATORY RESPONSES; IMMUNE-RESPONSES; BACTERIA; LACTOBACILLUS; PROBIOTICS; GUT; HOMEOSTASIS; GENERATION; STRAINS; DISEASE

Domaines: Sciences agricoles

Ghalia G. Kaci, Omar O. Lakhdari, Joel J. Dore, Stanislav S. Ehrlich, Pierre Renault, et al.. Inhibition of the NF-kappa B Pathway in Human Intestinal Epithelial Cells by Commensal Streptococcus salivarius. Applied and Environmental Microbiology, 2011, 77 (13), pp.4681 - 4684. ⟨10.1128/AEM.03021-10⟩. ⟨hal-01004341⟩