Design of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities.

Clément Fontenelle (1) , Zhong Wang (1) , Christine Fossey (2) , Bruno Linclau (1) , Thomas Cailly (2) , Frédéric Fabis (2)

1 School of Chemistry [Southampton, UK]
2 CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie

Domaines: Chimie thérapeutique

Clément Fontenelle, Zhong Wang, Christine Fossey, Bruno Linclau, Thomas Cailly, et al.. Design of fluorinated 5-HT4R antagonists: Influence of the basicity and lipophilicity toward the 5-HT4R binding affinities.. Bioorganic and Medicinal Chemistry, 2013, 21, pp.7529 - 7538. ⟨hal-00918408⟩