Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman

Daniel Baron , Frank Batista , Stéphane Chaffaux , Julie Cocquet , Corinne Cotinot , Edmond Cribiu , Elfride de Baeree , Yann Guiguen , Francis Jaubert , Eric Pailhoux , Maëlle Pannetier , Daniel Vaiman , Bernard Vigier , Reiner Veitia , Marc Fellous

In this review, we describe recent results concerning the genetics of sex determination in mammals. Particularly, we developed the study of the FOXL2 gene and its implication in genetic anomalies in goats (PIS mutation) and humans (BPES). We present the expression of FOXL2 in the ovaries of different species.

Mots clés: ovary; comparative genomics; FOXL2; PIS; BPES

Domaines: Biologie de la reproduction; Alimentation et Nutrition; Biologie du développement

Daniel Baron, Frank Batista, Stéphane Chaffaux, Julie Cocquet, Corinne Cotinot, et al.. Foxl2 gene and the development of the ovary: a story about goat, mouse, fish and woman. Reproduction Nutrition Development, 2005, 45 (3), pp.377-382. ⟨10.1051/rnd:2005028⟩. ⟨hal-00900568⟩