Review of 5-HT4R ligands: state of art and clinical applications.

Ronan Bureau (1) , Michel Boulouard (2) , François Dauphin (2) , Frank Lezoualc'H , Sylvain Rault

1 CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie
2 GMPc - Groupe Mémoire et Plasticité comportementale

This article reviews the medicinal implications of 5-HT(4)R in the peripheral and central nervous systems, based on data from two hundred bibliographic references. An exhaustive compilation of molecules reported to be antagonists or agonists for 5-HT(4)R is presented, including chemical structures, binding properties and pharmacological profiles. In the last part of the review, some key concepts concerning structure-activity relationships are highlighted.

Domaines: Neurosciences

Ronan Bureau, Michel Boulouard, François Dauphin, Frank Lezoualc'H, Sylvain Rault. Review of 5-HT4R ligands: state of art and clinical applications.. Current Topics in Medicinal Chemistry, 2010, 10 (5), pp.527-53. ⟨hal-00863093⟩