N-Tosylcarboxamide as a Transformable Directing Group for Pd-Catalyzed C-H Ortho-Arylation

Florent Péron (1) , Christine Fossey (1) , Thomas Cailly (1) , Frédéric Fabis (1)

1 CERMN - Centre d'Etudes et de Recherche sur le Médicament de Normandie

The N-tosylcarboxamide group offers the possibility of directing the Pd-catalyzed C–H arylation of arenes providing a new entry to biarylcarboxamides. Moreover, its ability to react according to different reaction conditions including intramolecular reactions makes it a pivotal directing group for a divergent synthesis of biaryl-based compounds

Mots clés: Hydrocarbons; Organic reactions; Addition reactions; Arylation; Materials

Domaines: Chimie organique

Florent Péron, Christine Fossey, Thomas Cailly, Frédéric Fabis. N-Tosylcarboxamide as a Transformable Directing Group for Pd-Catalyzed C-H Ortho-Arylation. Organic Letters, 2012, 14, pp.1827-1829. ⟨10.1021/ol3004244⟩. ⟨hal-00821457⟩