Personalisation of a 3D Ventricular Electrophysiological Model, Using Endocardial and Epicardial Contact Mapping and MRI

J. Relan (1) , Maxime Sermesant (1) , H. Delingette (1) , Nicholas Ayache (1)

1 ASCLEPIOS - Analysis and Simulation of Biomedical Images

Personalisation, i.e. parameter estimation of a cardiac ElectroPhysiology (EP) model is needed to build patient-specific models, which could then be used to understand and predict the complex dynamics involved in patient's pathology. In this paper, we present an EP model personalisation approach applied to an infarcted porcine heart, using contact mapping data and Diffusion Tensor MRI. The contact mapping data was gathered during normal sinus rhythm, on the ventricles in-vivo, endocardially as well as epicardially, using a CARTO mapping system. The Diffusion Tensor MRI was then obtained ex-vivo, in order to have the true cardiac fibre orientations, for the infarcted heart. Both datasets were then used to build and personalise the 3D ventricular electrophysiological model, with the proposed personalisation approach. Secondly, the effect of using only endocardial mapping or epicardial mapping measurements, on the personalised EP model was also tested.

Domaines: Imagerie médicale; Traitement des images [eess.IV]; Traitement du signal et de l'image [eess.SP]; Traitement du signal et de l'image [eess.SP]; Modélisation et simulation

J. Relan, Maxime Sermesant, H. Delingette, Nicholas Ayache. Personalisation of a 3D Ventricular Electrophysiological Model, Using Endocardial and Epicardial Contact Mapping and MRI. Statistical Atlases and Computational Models of the Heart. Imaging and Modelling Challenges - Second International Workshop, STACOM 2011, Held in Conjunction with MICCAI 2011, 2011, Toronto, Canada. pp.14-22, ⟨10.1007/978-3-642-28326-0_2⟩. ⟨hal-00813804⟩