C. Rivière, S. Roux, O. Tillement, C. Billotey, and P. Perriat, Nanosystems for medical applications : biological detection, drug delivery, diagnosis and therapy, Annales de Chimie Science des Mat??riaux, vol.31, issue.3, pp.351-367, 2006.
DOI : 10.3166/acsm.31.351-367

B. Godin, J. Sakamoto, R. Serda, A. Grattoni, A. Bouamrani et al., Emerging applications of nanomedicine for the diagnosis and treatment of cardiovascular diseases, Trends in Pharmacological Sciences, vol.31, issue.5, pp.199-205, 2010.
DOI : 10.1016/j.tips.2010.01.003

S. Hobbs, W. Monsky, F. Yuan, W. Roberts, L. Griffith et al., Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment, Proceedings of the National Academy of Sciences, vol.95, issue.8, pp.4607-4612, 1998.
DOI : 10.1073/pnas.95.8.4607

H. Maeda, J. Fang, T. Inutsuka, and Y. Kitamoto, Vascular permeability enhancement in solid tumor: various factors, mechanisms involved and its implications, International Immunopharmacology, vol.3, issue.3, pp.319-328, 2003.
DOI : 10.1016/S1567-5769(02)00271-0

M. Ferrari, Cancer nanotechnology: opportunities and challenges, Nature Reviews Cancer, vol.62, issue.3, pp.161-171, 2005.
DOI : 10.1038/nrc1566

M. Lewin, N. Carlesso, C. Tung, X. Tang, C. D. Scadden et al., Tat peptidederivatized magnetic nanoparticles allow in vivo tracking and recovery of progenitor cells, Nat Biotechnol, vol.18, pp.410-414, 2000.

J. Kim, Y. Piao, and T. Hyeon, Multifunctional nanostructured materials for multimodal imaging, and simultaneous imaging and therapy, Chem. Soc. Rev., vol.4, issue.2, pp.372-390, 2009.
DOI : 10.1039/B709883A

K. Kobayashi, N. Usami, E. Porcel, S. Lacombe, L. Sech et al., Enhancement of radiation effect by heavy elements, Mutation Research/Reviews in Mutation Research, vol.704, issue.1-3, pp.123-131, 2010.
DOI : 10.1016/j.mrrev.2010.01.002

C. Alric, J. Taleb, L. Duc, G. Mandon, C. Billotey et al., Gadolinium Chelate Coated Gold Nanoparticles As Contrast Agents for Both X-ray Computed Tomography and Magnetic Resonance Imaging, Journal of the American Chemical Society, vol.130, issue.18, pp.5908-5915, 2008.
DOI : 10.1021/ja078176p

URL : https://hal.archives-ouvertes.fr/hal-00433987

J. Hainfeld, D. Slatkin, and H. Smilowitz, The use of gold nanoparticles to enhance radiotherapy in mice, Physics in Medicine and Biology, vol.49, issue.18, pp.309-315, 2004.
DOI : 10.1088/0031-9155/49/18/N03

J. Hainfled, F. Dilmanian, D. Sltakin, and H. Smilowitz, Radiotherapy enhancement with gold nanoparticles, Journal of Pharmacy and Pharmacology, vol.169, issue.8, pp.977-985, 2008.
DOI : 10.1211/jpp.60.8.0005

P. Sharma, S. Brown, G. Walter, S. Santra, E. Scott et al., Gd nanoparticulates: from magnetic resonance imaging to neutron capture therapy, Advanced Powder Technology, vol.18, issue.6, pp.663-698, 2007.
DOI : 10.1163/156855207782515030

J. Bridot, A. Faure, S. Laurent, C. Rivière, C. Billotey et al., Hybrid Gadolinium Oxide Nanoparticles:?? Multimodal Contrast Agents for in Vivo Imaging, Journal of the American Chemical Society, vol.129, issue.16, pp.5076-5084, 2007.
DOI : 10.1021/ja068356j

URL : https://hal.archives-ouvertes.fr/hal-00434120

P. Mowat, A. Mignot, R. W. Lux, F. Tillement, O. Roulin et al., <I>In Vitro</I> Radiosensitizing Effects of Ultrasmall Gadolinium Based Particles on Tumour Cells, Journal of Nanoscience and Nanotechnology, vol.11, issue.9, pp.7833-7839, 2011.
DOI : 10.1166/jnn.2011.4725

L. Duc, G. Miladi, I. Alric, C. Mowat, P. Bräuer-krisch et al., Toward an Image-Guided Microbeam Radiation Therapy Using Gadolinium-Based Nanoparticles, ACS Nano, vol.5, issue.12, pp.9566-9574, 2011.
DOI : 10.1021/nn202797h

J. Fizet, C. Rivière, J. Bridot, N. Charvet, C. Louis et al., Multi-Luminescent Hybrid Gadolinium Oxide Nanoparticles as Potential Cell Labeling, Journal of Nanoscience and Nanotechnology, vol.9, issue.10, pp.5717-5725, 2009.
DOI : 10.1166/jnn.2009.1237

F. Lux, A. Mignot, P. Mowat, C. Louis, S. Dufort et al., Ultrasmall Rigid Particles as Multimodal Probes for Medical Applications, Angewandte Chemie International Edition, vol.30, issue.51, pp.12299-12303, 2011.
DOI : 10.1002/anie.201104104

URL : https://hal.archives-ouvertes.fr/inserm-00658275

P. Xu, E. Gullotti, L. Tong, C. Highley, D. Errabelli et al., -glycolic acid) Nanoparticles, Revisited, Molecular Pharmaceutics, vol.6, issue.1, pp.190-201424, 1995.
DOI : 10.1021/mp800137z

URL : https://hal.archives-ouvertes.fr/cea-01058940

W. Löscher and H. Potschka, Role of drug efflux transporters in the brain for drug disposition and treatment of brain diseases, Progress in Neurobiology, vol.76, issue.1, pp.22-76, 2005.
DOI : 10.1016/j.pneurobio.2005.04.006

S. Conner and S. Schmid, Regulated portals of entry into the cell, Nature, vol.277, issue.6927, pp.37-44, 2003.
DOI : 10.1038/nature01451

A. Kumari and S. Yadav, Cellular interactions of therapeutically delivered nanoparticles, Expert Opinion on Drug Delivery, vol.5, issue.5, pp.141-151, 2011.
DOI : 10.1080/10915810600959543

Z. Wang, C. Tiruppathi, R. Minshall, and A. Malik, Size and Dynamics of Caveolae Studied Using Nanoparticles in Living Endothelial Cells, ACS Nano, vol.3, issue.12, pp.4110-4116, 2009.
DOI : 10.1021/nn9012274

K. Thurn, H. Arora, T. Paunesku, A. Wu, E. Brown et al., Endocytosis of titanium dioxide nanoparticles in prostate cancer PC-3M cells, Nanomedicine: Nanotechnology, Biology and Medicine, vol.7, issue.2, pp.123-130, 2011.
DOI : 10.1016/j.nano.2010.09.004

S. Dufort, L. Sancey, and J. Coll, Physico-chemical parameters that govern nanoparticles fate also dictate rules for their molecular evolution, Advanced Drug Delivery Reviews, vol.64, issue.2, pp.179-189, 2012.
DOI : 10.1016/j.addr.2011.09.009

H. Meng, S. Yang, Z. Li, T. Xia, J. Chen et al., Aspect Ratio Determines the Quantity of Mesoporous Silica Nanoparticle Uptake by a Small GTPase-Dependent Macropinocytosis Mechanism, ACS Nano, vol.5, issue.6, pp.4434-4447, 2011.
DOI : 10.1021/nn103344k

H. Yoo and T. Park, Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA???PEG block copolymer, Journal of Controlled Release, vol.70, issue.1-2, pp.63-70, 2001.
DOI : 10.1016/S0168-3659(00)00340-0

T. Johnson, D. Rowe, B. Nelson, and N. Swanson, Squamous cell carcinoma of the skin (excluding lip and oral mucosa), Journal of the American Academy of Dermatology, vol.26, issue.3, pp.467-484, 1992.
DOI : 10.1016/0190-9622(92)70074-P

Z. Salehi, F. Mashayekhi, and F. Shahosseini, Significance of eIF4E expression in skin squamous cell carcinoma, Cell Biology International, vol.31, issue.11, pp.1400-1404, 2007.
DOI : 10.1016/j.cellbi.2007.06.006

M. Aloy, E. Hadchity, C. Bionda, C. Diaz-latoud, C. L. Rousson et al., Protective Role of Hsp27 Protein Against Gamma Radiation???Induced Apoptosis and Radiosensitization Effects of Hsp27 Gene Silencing in Different Human Tumor Cells, International Journal of Radiation Oncology*Biology*Physics, vol.70, issue.2, pp.543-553, 2008.
DOI : 10.1016/j.ijrobp.2007.08.061

URL : https://hal.archives-ouvertes.fr/hal-00193388

N. Abrikossova, C. Skoglund, M. Ahren, T. Bengtsson, and K. Uvdal, Effects of gadolinium oxide nanoparticles on the oxidative burst from human neutrophil granulocytes, Nanotechnology, vol.23, issue.27, p.275101, 2012.
DOI : 10.1088/0957-4484/23/27/275101

C. Louis, R. Bazzi, C. Marquette, J. Bridot, S. Roux et al., Nanosized Hybrid Particles with Double Luminescence for Biological Labeling, Chemistry of Materials, vol.17, issue.7, pp.1673-1682, 2005.
DOI : 10.1021/cm0480162

URL : https://hal.archives-ouvertes.fr/hal-00436804

R. Bazzi, M. Flores, C. Louis, K. Lebbou, W. Zhang et al., Synthesis and properties of europium-based phosphors on the nanometer scale: Eu2O3, Gd2O3:Eu, and Y2O3:Eu, Journal of Colloid and Interface Science, vol.273, issue.1, pp.191-197, 2004.
DOI : 10.1016/j.jcis.2003.10.031

H. Choi, W. Liu, K. Nasr, P. Misra, M. Bawendi et al., Design considerations for tumour-targeted nanoparticles, Nature Nanotechnology, vol.13, issue.1, pp.42-47, 2010.
DOI : 10.1038/nnano.2009.314

B. Mutelet, N. Keller, S. Roux, M. Flores-gonzales, F. Lux et al., Size-induced effect upon the N??el temperature of the antiferro/paramagnetic transition in gadolinium oxide nanoparticles, Applied Physics A, vol.41, issue.1, pp.215-219, 2011.
DOI : 10.1007/s00339-011-6492-z

A. Simon-deckers, B. Gouget, M. Mayne-l-'hermite, N. Herlin-boime, C. Reynaud et al., In vitro investigation of oxide nanoparticle and carbon nanotube toxicity and intracellular accumulation in A549 human pneumocytes, Toxicology, vol.253, issue.1-3, pp.137-146, 2008.
DOI : 10.1016/j.tox.2008.09.007

URL : https://hal.archives-ouvertes.fr/hal-00331950

L. Sancey, E. Garanger, S. Foillard, G. Schoehn, A. Hurbin et al., Clustering and internalization of integrin alphavbeta3 with a tetrameric RGD-synthetic peptide, Mol Ther, vol.17, p.837, 2009.
URL : https://hal.archives-ouvertes.fr/inserm-00369024

P. Watson, A. Jones, and D. Stephens, Intracellular trafficking pathways and drug delivery: fluorescence imaging of living and fixed cells, Advanced Drug Delivery Reviews, vol.57, issue.1, pp.43-61, 2005.
DOI : 10.1016/j.addr.2004.05.003

F. Maxfield and T. Mcgraw, Endocytic recycling, Nature Reviews Molecular Cell Biology, vol.5, issue.2, pp.121-132, 2004.
DOI : 10.1038/nrm1315