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Ultrasmall rigid particles as multimodal probes for medical applications.

François Lux 1 Anna Mignot 1, 2, 3 Pierre Mowat 1 Cédric Louis 3 Sandrine Dufort 3 Claire Bernhard 4 Franck Denat 4 Frédéric Boschetti 5 Claire Brunet 6 Rodolphe Antoine 6 Philippe Dugourd 6 Sophie Laurent 7, 8 Luce Vander Elst 7, 8 Robert Muller 7, 8 Lucie Sancey 9 Véronique Josserand 9 Jean-Luc Coll 10 Vasile Stupar 11 Emmanuel Barbier 11 Chantal Rémy 11 Alexis Broisat 12 Catherine Ghezzi 12 Géraldine Le Duc 13 Stéphane Roux 14 Pascal Perriat 2, * Olivier Tillement 1
Résumé : Ultrasmall but multifunctional: Rigid imaging particles that are smaller than 5 nm in size can be obtained in a top-down process starting from a core–shell structure (core=gadolinium oxide; shell=polysiloxane). They represent the first multifunctional silica-based particles that are sufficiently small to escape hepatic clearance and enable animal imaging by four complementary techniques
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Submitted on : Tuesday, January 10, 2012 - 11:04:35 AM
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François Lux, Anna Mignot, Pierre Mowat, Cédric Louis, Sandrine Dufort, et al.. Ultrasmall rigid particles as multimodal probes for medical applications.. Angewandte Chemie International Edition, Wiley-VCH Verlag, 2011, 50 (51), pp.12299-303. ⟨10.1002/anie.201104104⟩. ⟨inserm-00658275⟩

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