Near-Infrared Fluorescence (NIRF) Imaging in Breast-Conserving Surgery: Assessing Intraoperative Techniques in Tissue-Simulating Breast Phantoms

R.G. Pleijhuis (1, 2) , G.C. Langhout (1, 2) , W. Helfrich (1, 2) , G. Themelis (3) , A. Sarantopoulos (3) , L.M.A. Crane (1, 2) , N.J. Harlaar (1, 2) , J.S. de Jong (2, 4) , V. Ntziachristos (3) , G.M. van Dam (1, 2)

1 Department of surgery
2 UMCG - University Medical Center Groningen [Groningen]
3 IBMI - Institute for Biological and Medical Imaging [Neuherberg]
4 Department of Surgery

Breast-conserving surgery (BCS) results in tumour-positive surgical margins in up to 40% of the patients. Therefore, new imaging techniques are needed that support the surgeon with real-time feedback on tumour location and margin status. In this study, the potential of near-infrared fluorescence (NIRF) imaging in BCS for pre- and intraoperative tumour localization, margin status assessment and detection of residual disease was assessed in tissue-simulating breast phantoms.

Mots clés: Human breast cancer; near-infrared fluorescence; tissue-simulating phantoms; intraoperative imaging

R.G. Pleijhuis, G.C. Langhout, W. Helfrich, G. Themelis, A. Sarantopoulos, et al.. Near-Infrared Fluorescence (NIRF) Imaging in Breast-Conserving Surgery: Assessing Intraoperative Techniques in Tissue-Simulating Breast Phantoms. EJSO - European Journal of Surgical Oncology, 2010, 37 (1), pp.32. ⟨10.1016/j.ejso.2010.10.006⟩. ⟨hal-00651624⟩