Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir

Tuija H. Nieminen (1) , Nora M. Hagelberg (1) , Teijo I. Saari (1) , Mikko Neuvonen (2) , Pertti J. Neuvonen (2) , Kari Laine (3) , Klaus T. Olkkola (1)

1 Department of Anaesthesiology, Intensive Care, Emergency Care and Pain Medicine
2 Department of Clinical Pharmacology
3 Department of Pharmacology, Drug Development & Therapeutics

Mots clés: Oxycodone; Ritonavir; Lopinavir/ritonavir; Interaction; Pharmacokinetics; Pharmacodynamics

Tuija H. Nieminen, Nora M. Hagelberg, Teijo I. Saari, Mikko Neuvonen, Pertti J. Neuvonen, et al.. Oxycodone concentrations are greatly increased by the concomitant use of ritonavir or lopinavir/ritonavir. European Journal of Clinical Pharmacology, 2010, 66 (10), pp.977-985. ⟨10.1007/s00228-010-0879-1⟩. ⟨hal-00614173⟩