A Review of Flow Cytometry and its Use in the Diagnosis and Management of Mature Lymphoid Malignancies

Ruth de Tute (1)

1 HMDS

The last decade has seen huge advances in flow cytometric immunophenotyping and this has expanded the utility of flow cytometry to investigate the antigens present on normal and neoplastic haematopoietic cells. This review summarises how flow cytometry is currently used in the diagnosis and management of mature lymphoid malignancies. The establishment of disease-specific phenotypes allows the creation of assays which can detect neoplastic cells with high specificity and sensitivity. Certain lymphoid neoplasms are immunophenotypically well defined whilst others are more heterogeneous. The availability of more sophisticated cytometers and a wider selection of antibodies in routine diagnostic laboratories may lead to the resolution of these more complex disease entities.

Mots clés: Medicine

Ruth de Tute. A Review of Flow Cytometry and its Use in the Diagnosis and Management of Mature Lymphoid Malignancies. Histopathology, 2011, 58 (1), pp.90. ⟨10.1111/j.1365-2559.2010.03703.x⟩. ⟨hal-00613813⟩