The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans

Henning Fedders (1) , Rainer Podschun (2) , Matthias Leippe (1)

1 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
2 Faculty of Medicine

Ci-MAM-A24, a synthetic antimicrobial peptide derived from a peptide precursor from immune cells of the marine invertebrate , has been shown to be potently active against representatives of Gram-positive and Gram-negative bacteria by permeabilising their cytoplasmic membrane. In the present study, the activity of Ci-MAM-A24 against different bacterial pathogens frequently causing therapeutic problems was tested. In particular, the killing capacity of Ci-MAM-A24 against clinically important anaerobic bacteria as well as multiresistant aerobic strains such as meticillin-resistant (MRSA), vancomycin-resistant enterococci, extended-spectrum β-lactamase-producers and multiple-resistant strains was monitored. Virtually all strains proved to be highly susceptible to Ci-MAM-A24 at low concentrations [minimum bactericidal concentration (MBC)<10μg/mL].

Mots clés: Antimicrobial peptide; Anaerobic bacteria; Multidrug-resistant bacteria; Ci-MAM-A24

Henning Fedders, Rainer Podschun, Matthias Leippe. The antimicrobial peptide Ci-MAM-A24 is highly active against multidrug-resistant and anaerobic bacteria pathogenic for humans. International Journal of Antimicrobial Agents, 2010, 36 (3), pp.264. ⟨10.1016/j.ijantimicag.2010.04.008⟩. ⟨hal-00608986⟩