In vitro Anti HSV-1 and HSV-2 Activity of Tanacetum vulgare Extracts and Isolated Compounds: An Approach to their Mechanisms of Action.

Ángel L Álvarez (1) , Solomon Habtemariam (2) , Malindra Juan-Badaturuge (2) , Caroline Jackson (3) , Francisco Parra (4)

1 Instituto Universitario de Biotecnología de Asturias
2 Pharmacognosy Research Laboratories
3 Hadlow College
4 Instituto Universitario de Biotecnología de Asturias

Herpes simplex viruses (HSV-1 and HSV-2) are responsible for long-term latent infections in humans, with periods of recurring viral replication associated to lesions around the lips, eyes, mucous membrane of the oral cavity or the genitals. The lack of an effective vaccine, the moderate to high toxicity of the available synthetic anti-herpes compounds and the appearance of resistant viral strains emphasise the need for new inhibitors. Tanacetum vulgare, commonly known as tansy, has been used for treating rheumatic pain, skin eruption, and diuretic conditions as well as anthelmintic, antihypertensive, stimulant, emmenagogue, carminative, antiseptic, antihypertensive, antispasmodic and antioxidant agent. The anti HSV-1 activity of tansy aerial parts, ethyl acetate extract and the isolated compound parthenolide, has recently been reported. In this work, through a comprehensive mechanistic-based antiherpetic activity study, we revealed that constituents other than parthenolide are responsible for the antiviral activity of tansy.

Mots clés: Life Sciences

Ángel L Álvarez, Solomon Habtemariam, Malindra Juan-Badaturuge, Caroline Jackson, Francisco Parra. In vitro Anti HSV-1 and HSV-2 Activity of Tanacetum vulgare Extracts and Isolated Compounds: An Approach to their Mechanisms of Action.. Phytotherapy Research, 2010, ⟨10.1002/ptr.3382⟩. ⟨hal-00601639⟩