Skip to Main content Skip to Navigation
Journal articles

Genetic risk profiles for depression and anxiety in adult and elderly cohorts

Abstract : The first generation of genome-wide association studies (GWA studies) for psychiatric disorders has led to new insights regarding the genetic architecture of these disorders. We now start to realize that a larger number of genes, each with a small contribution, are likely to explain the heritability of psychiatric diseases. The contribution of a large number of genes to complex traits can be investigated with genome-wide profiling. In a discovery sample a genetic risk profile for depression was defined based on a GWA study of 1738 adult cases and 1802 controls. The genetic risk scores were tested in two population based samples of elderly participants. The genetic risk profiles were evaluated for depression and anxiety in the Rotterdam Study cohort and the Erasmus Rucphen Family (ERF) study. The genetic risk scores were significantly associated to different measures of depression and explained up to ~0.7% of the variance in depression in Rotterdam Study and up to ~1 % in ERF study. The genetic score for depression was also significantly associated to anxiety explaining up to 2.1% in Rotterdam study. These findings suggest the presence of many genetic loci of small effect that influence both depression and anxiety. Remarkably, the predictive value of these profiles was as large in the sample of elderly participants as in the middle-aged samples.
Document type :
Journal articles
Complete list of metadata

Cited literature [52 references]  Display  Hide  Download

https://hal.archives-ouvertes.fr/hal-00549430
Contributor : Hal Peer <>
Submitted on : Wednesday, December 22, 2010 - 2:53:15 AM
Last modification on : Thursday, April 19, 2018 - 2:24:03 PM
Long-term archiving on: : Friday, December 2, 2016 - 8:00:27 PM

File

PEER_stage2_10.1038%2Fmp.2010....
Files produced by the author(s)

Identifiers

Collections

Citation

Ayse Demirkan, Brenda W.J.H. Penninx, Karin Hek, Naomi Wray, Najaf Amin, et al.. Genetic risk profiles for depression and anxiety in adult and elderly cohorts. Molecular Psychiatry, Nature Publishing Group, 2010, ⟨10.1038/mp.2010.65⟩. ⟨hal-00549430⟩

Share

Metrics

Record views

148

Files downloads

256