Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes

Jana Reinemund , Kerstin Seidel , Ulrike M. Steckelings , Daniela Zaade , Sabrina Klare , Franziska Rompe , Marlen Katerbaum , Jens Schacherl , Yaosi Li , Mario Menk , Jan H. Schefe , Petra Goldin-Lang , Csaba Szabo , Gabor Olah , Thomas Unger , Heiko Funke-Kaiser

The renin-angiotensin system (RAS) plays a crucial role in cardiovascular and neuronal (patho-)physiology. The angiotensin AT2 receptor (AT2R) seems to counteract the proinflammatory, prohypertrophic and profibrotic actions of the AT1 receptor. Recently, we identified a novel protein, termed “AT2R binding protein” (ATBP/ATIP) which seems essential for AT2R mediated growth inhibition. Poly(ADP-ribose) polymerase-1 (PARP-1) can act as a nuclear integrator of angiotensin II-mediated cell signalling, and has been implicated in the pathogenesis of cardiovascular and neuronal disease.

Mots clés: RAS; AT1R; AT2R; PARP-1; SHP-1; PLZF; ATBP; ATIP; MTSG; PAR; MEFs; RLA; ChIP; TBP; Renin-angiotensin system (RAS); Promoter; Angiotensin AT2 receptor; ATBP genes; Cardiovascular pathophysiology

Jana Reinemund, Kerstin Seidel, Ulrike M. Steckelings, Daniela Zaade, Sabrina Klare, et al.. Poly(ADP-ribose) polymerase-1 (PARP-1) transcriptionally regulates angiotensin AT2 receptor (AT2R) and AT2R binding protein (ATBP) genes. Biochemical Pharmacology, 2009, 77 (12), pp.1795. ⟨10.1016/j.bcp.2009.02.025⟩. ⟨hal-00493500⟩