miR-155 gene: A typical multifunctional microRNA

Isabella Faraoni , Francesca Romana Antonetti , John Cardone , Enzo Bonmassar

In the last years small RNA molecules, i.e. microRNA (miRNA) encoded by miR genes, have been found to play a crucial role in regulating gene expression of a considerable part of plant's and animal's genome. Here, we report the essential information on biogenesis of miRNAs and recent evidence on their important role in human diseases. Emphasis has been given to miR-155, since this molecule represents a typical multifunctional miRNA. Recent data indicate that miR-155 has distinct expression profiles and plays a crucial role in various physiological and pathological processes such as haematopoietic lineage differentiation, immunity, inflammation, cancer, and cardiovascular diseases. Moreover, miR-155 has been found to be implicated in viral infections, particularly in those caused by DNA viruses.

Mots clés: miR; miRNA; pri-miRNA; DGCR8; TRBP; PACT; RISC; AGO; siRNAs; CLL; PD; AD; FGF20; BACE 1; AT1R; BIC; HSC; LPS; poly IC; TNF-α; JNK; RA; BCR; TCR; MMPs; AID; FADD; IKKɛ; RIPK1; TP53INP1; PMBL; DLBCL; GCB; ABC; ALL; AML; PDAC; Ang II; KSHV; EBV; miRNAs; miR-155; Hematopoiesis; Inflammation; Immunity; Cancer; Lymphoma; Leukemia

Isabella Faraoni, Francesca Romana Antonetti, John Cardone, Enzo Bonmassar. miR-155 gene: A typical multifunctional microRNA. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2009, 1792 (6), pp.497. ⟨10.1016/j.bbadis.2009.02.013⟩. ⟨hal-00488806⟩