Dielectric Characterization of Biological Tissues: Constraints Related to Ex Vivo Measurements

Mustapha Nadi (1)

1 LIEN - Laboratoire d'Instrumentation Electronique de Nancy

Electrical Impedance Spectroscopy (EIS) has been previously reported as a technique for non-invasive assessment of electromagnetic tissue properties. In the frequency range up to 10 MHz, current conduction through tissue is mainly determined by the tissue structure, i.e. the extra- and intra-cellular compartments and the insulating cell membranes. Therefore, changes in the extra- and intra-cellular fluid volumes are reflected in the impedance spectra. E.I.S. systems include electrodes for the measurement of the impedance. Different electrodes configurations are used to measure bioelectric phenomenon for both macroscopic and microscopic approaches. Electrodes for macroscopic characterization are used for bio impedance measurement of a great biological tissue sample or organ. In this paper, we briefly review and discuss metrological aspects relating to electrical characterization of biological tissues based on the difficulty to compare between different author's results. Experimental results obtained on different kinds of biological tissues (blood and bone) are presented and discussed as examples according to the influencing constraints specific to their physiological nature.

Mots clés: Keywords Bioimpedance; dielectric properties; blood; bone; microelectrodes; biological sensor; electromagnetic dosimetry; impedance spectroscopy

Domaines: Electronique

Mustapha Nadi. Dielectric Characterization of Biological Tissues: Constraints Related to Ex Vivo Measurements. S.C. Mukhopadhyay and R.Y.M. Huang. Sensors, Springer Berlin Heidelberg, pp.75-90, 2008, Lecture Notes in Electrical Engineering, ⟨10.1007/978-3-540-69033-7_5⟩. ⟨hal-00322097⟩