Hemocompatibility evaluation of DLC-and SiC- coated surfaces

N. Nurdin , P. François , Yannick Mugnier (1) , J. Krumeich , M. Moret , B.O. Aransson , P. Descouts

1 SYMME - Laboratoire SYstèmes et Matériaux pour la MEcatronique

Diamond-like carbon (DLC) and silicon carbide (SiC) coat- ings are attractive because of low friction coefficient, high hardness, chemical inertness and smooth finish, which they provide to biomedical devices. Silicon wafers (Si and silicone rubber (Si) plates were coated using plasma- enhanced chemical vapour deposition (PE-CVD) tech- niques. This article describes: 1- the characterization of modified surfaces using attenuated total reflection-Fourier transform infrared spectroscopy (ATR/FTIR) and contact angle measurements, 2- the results of three in-vitro haemocompatibility assays. Coated surfaces were compared to uncoated materials and various substrates such as polymethylmethacrylate (PMMA), polyethylene (LDPE), polydimethylsiloxane (PDMS) and medical steel (MS). Thrombin generation, blood platelet adhesion and com- plement convertase activity tests revealed the following classification, from the most to the least heamocompatible

Mots clés: complement convertase attachment; Diamond-like carbon coating; plasma depo- sition; platelet adhesion; thrombin generation; complement convertase attachment.

Domaines: Matériaux et structures en mécanique [physics.class-ph]; Matériaux et structures en mécanique [physics.class-ph]

N. Nurdin, P. François, Yannick Mugnier, J. Krumeich, M. Moret, et al.. Hemocompatibility evaluation of DLC-and SiC- coated surfaces. eCells and Materials Journal, 2003, 13, pp. 17-28. ⟨hal-00258326⟩