Irradiation damage of uridine molecule with MeV heavy ions

J. Xue (1) , Y. Xie (1) , Lin Chen (1) , K. Jin (1) , Y. Wang (1)

1 SKL-NPT - State Key Laboratory of Nuclear Physics and Technology

To study the direct damage mechanism of energetic heavy ions irradiating nucleotides, the residual ratio of uridine molecules after irradiation was measured with High performance Liquid Chromatography (HPLC). The experimental result shows that, irradiation damage probability depends on the electronic energy loss ( Se ) of the incident ions, and it increases quickly when Se increases, and then it becomes stable when Se is higher than 800 eV/nm. The contribution of the nuclear collision could be neglected compared with that of the electronic process. This is not only because that the magnitude of nuclear energy loss ( Sn ) is much smaller than that of Se for heavy ions with MeV energies, but also because that the energy deposited thorough electronic process is more efficient in damaging molecules than that through the nuclear collision.

Mots clés: Irradiation damage; HPLC; heavy ion; energy loss

Domaines: Biophysique [physics.bio-ph]

J. Xue, Y. Xie, Lin Chen, K. Jin, Y. Wang. Irradiation damage of uridine molecule with MeV heavy ions. The Seventh International Symposium on Swift Heavy Ions in Matter, Jun 2008, Lyon, France. ⟨hal-00216211⟩