The concerted modulation of proliferation and migration contributes to the specification of the cytoarchitecture and dimensions of cortical areas

Agnès Lukaszewicz (1) , Véronique Cortay (1) , Pascale Giroud (1) , Michel Berland (2) , Iain H. M. Smart (3) , Henry Kennedy (1) , Colette Dehay (1)

1 Cerveau et vision
2 Service Gynécologie Obstétrique
3 Department of Anatomy and Physiology, School of life sciences

Regionalization of cell-cycle kinetics of cortical precursors has been described in non-human primates and rodents indicating a fate map of areal distinct proliferative programs in the germinal zones of the neocortex. It remains to be understood how proliferative gradients during corticogenesis are transcribed into a stepwise function to form adult areal borders. Here we have used the monkey areas17 and 18, which show striking cytoarchitectonic differences as a model system for studying how developmental events establish areal boundaries in the adult. We present data indicating that the events that are involved in the formation of a sharp border separating two areas involve an orchestration of diverse phenomena including differential rates of proliferation, migration and tangential expansion.

Mots clés: primate; neocortex; subventricular zone; cortical plate.; cortical plate

Domaines: Neurosciences [q-bio.NC]

Agnès Lukaszewicz, Véronique Cortay, Pascale Giroud, Michel Berland, Iain H. M. Smart, et al.. The concerted modulation of proliferation and migration contributes to the specification of the cytoarchitecture and dimensions of cortical areas. Cerebral Cortex, 2006, 16 Suppl 1, pp.i26-34. ⟨10.1093/cercor/bhk011⟩. ⟨hal-00077632⟩