COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

Md. Farhad Hossain (1, 2) , Sharifa Hasana (3) , Abdullah Al Mamun (2, 3) , Md. Sahab Uddin (2, 3) , Mir Imam Ibne Wahed (4) , Sabarni Sarker (5) , Tapan Behl (6) , Irfan Ullah (7) , Yesmin Begum (3) , Israt Jahan Bulbul (3) , Md. Shah Amran (8) , Md. Habibur Rahman (9) , May N. Bin-Jumah (10) , Saad Alkahtani (11) , Shaker A. Mousa (12) , Lotfi Aleya (13) , Mohamed M. Abdel-Daim (14)

1 Department of Physical Therapy, Graduate School of Inje University, Gimhae, South Korea
2 Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
3 Department of Pharmacy, Southeast University, Dhaka, Bangladesh
4 Department of Pharmacy, Faculty of Science, University of Rajshahi, Rajshahi, Bangladesh
5 Department of Pharmacy, Faculty of Life and Earth Sciences, Jagannath University, Dhaka, Bangladesh
6 Chitkara College of Pharmacy, Chitkara University, Punjab, India
7 Kabir Medical College, Gandhara University, Peshawar, Pakistan
8 Department of Pharmaceutical Chemistry, University of Dhaka, Dhaka, Bangladesh
9 Department of Global Medical Science, Yonsei University, Seoul, South Korea
10 Biology Department, College Of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia
11 KSU - King Saud University [Riyadh]
12 Pharmaceutical Research Institute, Albany College of Pharmacy and Health Sciences, New York, NY, United States
13 LCE - Laboratoire Chrono-environnement (UMR 6249)
14 Suez Canal University

At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).

Mots clés: coronavirus; coronavirus disease 2019; severe acute respiratory syndrome coronavirus-2; Middle East respiratory syndrome coronavirus; transmission; therapeutic interventions

Domaines: Sciences de l'environnement

Md. Farhad Hossain, Sharifa Hasana, Abdullah Al Mamun, Md. Sahab Uddin, Mir Imam Ibne Wahed, et al.. COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management. Frontiers in Pharmacology, 2020, 11, ⟨10.3389/fphar.2020.563478⟩. ⟨hal-02969134⟩