Genome analysis of enterobacteriaceae with non-wild type susceptibility to third-generation cephalosporins recovered from diseased dogs and cats in Europe

Line Pepin-Puget (1) , Farid El Garch (2) , Xavier Bertrand (3, 1) , Benoit Valot (3, 1) , Didier Hocquet (3, 1)

1 CHRU Besançon - Centre Hospitalier Régional Universitaire de Besançon
2 Vétoquinol
3 LCE - Laboratoire Chrono-environnement (UMR 6249)

Extended-spectrum-β-lactamases (ESBL) and plasmid-mediated cephalosporinases (pAmpC)-producing Enterobacteriaceae isolates are now reported worldwide in humans, animals, and in the environment. We identified the determinants of resistance to β-lactams and associated resistance genes as well as phylogenetic diversity of 53 ESBL- or pAmpC-producing Enterobacteriaceae isolated from dogs and cats in Europe.

Mots clés: Bacterial pathogens; Resistance; Whole-Genome sequencing; Antibiotics; bacterial evolution; insertion sequence; outbreak; Animals

Domaines: Bactériologie; Microbiologie et Parasitologie

Line Pepin-Puget, Farid El Garch, Xavier Bertrand, Benoit Valot, Didier Hocquet. Genome analysis of enterobacteriaceae with non-wild type susceptibility to third-generation cephalosporins recovered from diseased dogs and cats in Europe. Veterinary Microbiology, 2020, 242, pp.108601. ⟨10.1016/j.vetmic.2020.108601⟩. ⟨hal-02537485⟩