Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool

Jobin Jose (1) , Rajesh Kumar (2) , Seetha Harilal (2) , Githa Elizabeth (3) , Della Grace Thomas Parambi (4) , Ankitha Prabhu (5) , Sahab Uddin (5, 6) , Lotfi Aleya (7) , Hoon Kim (8) , Bijo Mathew (9)

1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Science, NITTE Deemed to be University, Mangalore 575018, India
2 Kerala University of Health Sciences, Thrissur, Kerala 680596, India
3 Department of Pharmacology, Grace College of Pharmacy, Palakkad, India
4 Department of Pharmaceutical Chemistry, Jouf University, Sakaka, Al Jouf-2014, Saudi Arabia
5 Department of Pharmacy, Southeast University, Dhaka, Bangladesh
6 Pharmakon Neuroscience Research Network, Dhaka, Bangladesh
7 LCE - Laboratoire Chrono-environnement (UMR 6249)
8 Department of Pharmacy, and Research Institute of Life Pharmaceutical Sciences, Sunchon National University, Suncheon 57922, Republic of Korea
9 Department of Pharmaceutical Chemistry, Division of Drug Design and Medicinal Chemistry Research Lab, Ahalia School of Pharmacy, Palakkad, Kerala 678557, India

According to a statistical survey conducted by the Global Cancer Observatory (a division of the World Health Organization), cancer remains as the major cause of death worldwide. The main reason why available therapies fail is that a “vicious cycle” in established which initiates multiple pathways and recurrence after metastasis. Hyperthermic treatment, which involves heating tumor tissues to a moderate temperature of 40–43 °C, has emerged as an effective strategy for treating tumors. This method is highly efficient at destroying tumor cells and does not induce the side effects of conventional cancer treatments. On the other hand, hyperthermic treatment method can be co-administered with conventional treatments. Nanotechnology had created huge opportunities in almost all areas of research, including the field of hyperthermic treatment. The utilization of magnetic nanopar- ticles (MNPs) offers functionalities not possible using conventional magnetic materials. In this review, we detail recent devel- opments and applications of MNPs for hyperthermic treatment and discuss future possibilities.

Mots clés: Hyperthermia; Magnetic nanoparticles; Cancer; Apoptosis; Metastasis

Domaines: Sciences de l'environnement

Jobin Jose, Rajesh Kumar, Seetha Harilal, Githa Elizabeth, Della Grace Thomas Parambi, et al.. Magnetic nanoparticles for hyperthermia in cancer treatment: an emerging tool. Environmental Science and Pollution Research, 2020, ⟨10.1007/s11356-019-07231-2⟩. ⟨hal-02421754⟩