Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates

Nasreddine Kanfar (1) , Ahmad Mehdi (2) , Pascal Dumy (1) , Sebastien Ulrich, (1) , Jean-Yves Winum (1)

1 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
2 ICGM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

The straightforward access to octafunctional "cubic" silsesquioxane platform grafter with pendant glyoxylic aldehydes is described. This clickable hybrid platform readily reacts with oxyamine or hydrazide compounds to provide, respectively, oxime and acylhydrazone conjugates, thereby offering a new and effective access from which one can elaborate multivalent systems for the targeting of biomolecules of interest.

Mots clés: hydrazone; ligations; multivalent platform; oxyamine; silsesquioxane

Domaines: Matériaux; Chimie organique

Nasreddine Kanfar, Ahmad Mehdi, Pascal Dumy, Sebastien Ulrich,, Jean-Yves Winum. Polyhedral Oligomeric Silsesquioxane (POSS) Bearing Glyoxylic Aldehyde as Clickable Platform Towards Multivalent Conjugates. Chemistry - A European Journal, 2017, 23, pp.1-4. ⟨10.1002/chem.201703794⟩. ⟨hal-01611638⟩