Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy.

Eija Bergroth , Marjut Roponen , Anne M Karvonen (1) , Leea Keski-Nisula , Sami Remes , Josef Riedler (2) , Caroline Roduit (3, 4) , Jean-Charles Dalphin (5) , Vincent Kaulek (5, 6) , Georg J Loss (7, 8, 9) , Roger Lauener , Maija-Riitta Hirvonen (10) , Jon Genuneit (11) , Elisabeth Schmausser-Hechfellner , Harald Renz , Petra I Pfefferle , Susanne Krauss-Etschmann (12) , Bianca Schaub , Erika von Mutius (13) , Juha Pekkanen

1 Department of Environmental Health
2 Kardinal Schwarzenberg’sches Krankenhaus
3 Children's Hospital
4 CK-CARE - Christine Kühne – Centre for Allergy Research and Education
5 LCE - Laboratoire Chrono-environnement (UMR 6249)
6 UFC - Université de Franche-Comté
7 Swiss Tropical and Public Health Institute [Basel]
8 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
9 Unibas - Université de Bâle = University of Basel = Basel Universität
10 Technical Research Centre of Finland
11 Institute of Epidemiology
12 Comprehensive Pneumology Center, Ludwig Maximilians University and Helmholtz Zentrum Muenchen, Member of the German Research Center for Lung Research, Großhadern, Germany
13 University of Munich

Respiratory tract infectious symptoms and illnesses are frequent during early childhood, but their risk factors, including the effect of early immune regulation, are less known. Aim of the study was to analyse whether stimulated cord blood cytokine production is associated with the frequency of respiratory tract infectious symptoms or infections during the first year of life. The study population consisted of children of mothers from farm or non-farm rural environment from Austria, Finland, Germany and Switzerland who participated in a prospective birth cohort study (PASTURE: Protection against Allergy - study in Rural Environments) (N=550). Cord blood samples were stimulated with the combination of phorbol ester and ionomycin (P/I) for 24 hours and the production of IL-5, IL-10, TNF-α and IFN-γ was determined by using ELISA. Information about infectious morbidity was collected using weekly diaries. P/I stimulated production of IL-5 (adjusted risk ratio (aRR) for ≤median production, 0.37; 95% Confidence Interval (CI), 0.25-0.55, aRR for >median production, 0.41; 95%CI, 0.27-0.61 vs. production median production, 0.39; 95% CI, 0.25-0.62 vs. production

Domaines: Santé

Eija Bergroth, Marjut Roponen, Anne M Karvonen, Leea Keski-Nisula, Sami Remes, et al.. Enhanced T helper 1 and 2 cytokine responses at birth associate with lower risk of middle ear infections in infancy.. Pediatric Allergy and Immunology, 2016. ⟨hal-01368330⟩