Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae.

Anne-Pauline Bellanger (1) , Nathaniel D Albert (2) , Russell E Lewis (3) , Thomas J Walsh (4, 5) , Dimitrios P Kontoyiannis (6)

1 LCE - Laboratoire Chrono-environnement (UMR 6249)
2 LERAP - Laboratoire d'études et de recherches sur l'action publique
3 Institute for Cell and Molecular Biosciences, Newcastle University
4 UNSW - University of New South Wales [Sydney]
5 NICTA - National ICT Australia [Sydney]
6 Institute of Immunology

Triazole prophylaxis has become the norm in patients with hematological malignancies. Breakthrough infections caused by Mucorales during triazole prophylaxis remain a challenging problem. We found that preexposure of Rhizopus oryzae to antifungal triazoles (fluconazole, voriconazole, posaconazole, and itraconazole) did not modify the in vitro susceptibility of Rhizopus oryzae to posaconazole. In contrast, preexposure of Rhizopus to triazoles was associated with the enhanced in vitro susceptibility of R. oryzae to amphotericin B. Preexposure to posaconazole did not alter the virulence of R. oryzae in the fly model of mucormycosis.

Domaines: Santé

Anne-Pauline Bellanger, Nathaniel D Albert, Russell E Lewis, Thomas J Walsh, Dimitrios P Kontoyiannis. Effect of Preexposure to Triazoles on Susceptibility and Virulence of Rhizopus oryzae.. Antimicrobial Agents and Chemotherapy, 2015, 59 (12), pp.7830-2. ⟨hal-01294667⟩