Theoretical study of amino derivatives and anticancer platinum drug grafted on various carbon nanostructures
Résumé
Density functional theory calculations with van der Waals approximation have been conducted to
analyze the functionalization of various carbon-based nanostructures (fullerene, metallic, and semi-
conducting nanotubes) with amino derivative groups. The results obtained with azomethine, show
the formation of a five membered ring on fullerenes, and on nanotubes consistent with experimental
observations. The attachment of an azomethine plus subsequent drug like a Pt(IV) complex does
not perturb the cycloaddition process. Moreover, all theoretical results show that the length of dif-
ferent amino derivatives with subsequent Pt(IV) complex does not affect the complexed therapeutic
agent when it is attached onto these carbon-based nanostructures.