Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation

M. Smadhi (1) , S. de Bentzmann (1) , A. Imberty (2) , M. Gingras (1) , R. Abderrahim (1) , P.G. Goekjian (1)

1 inconnu
2 CERMAV - Centre de Recherches sur les Macromolécules Végétales

Readily accessible, low-valency glycoclusters based on a triazine core bearing D-galactose and L-fucose epitopes are able to inhibit biofilm formation by Pseudomonas aeruginosa. These multivalent ligands are simple to synthesize, are highly soluble, and can be either homofunctional or heterofunctional. The galactose-decorated cluster shows good affinity for Pseudomonas aeruginosa lectin lecA. They are convenient biological probes for investigating the roles of lecA and lecB in biofilm formation.

Domaines: Polymères

M. Smadhi, S. de Bentzmann, A. Imberty, M. Gingras, R. Abderrahim, et al.. Expeditive synthesis of trithiotriazine-cored glycoclusters and inhibition of Pseudomonas aeruginosa biofilm formation. Beilstein Journal of Organic Chemistry, 2014, 10, pp.1981-1990. ⟨hal-01066711⟩