Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.

Hanane Elayadi (1) , Michael Smietana (2) , Jean-Jacques Vasseur (2) , Jan Balzarini (3) , Hassan B. Lazrek (1)

1 URAC 16 - Laboratoire de Chimie Biomoléculaire Substances Naturelles et Réactivité
2 IBMM - Institut des Biomolécules Max Mousseron [Pôle Chimie Balard]
3 Rega Institute for Medical Research [Leuven, België]

Montmorillonite K10 impregnated with copper dichloride and potassium iodide (CuCl2/KI/K10) was used as catalyst in the cycloaddition of azides and propargylnucleobases, to provide the corresponding 1,4-disubstituted 1,2,3-triazoles in good yield. All compounds 16-23 were evaluated for their antiviral activity in vitro. Compound 18 showed moderate inhibition against influenza virus A (H3N2).

Mots clés: Anti-influenza A (H3N2); Click reaction; 3-Triazolyl nucleoside

Domaines: Chimie organique

Hanane Elayadi, Michael Smietana, Jean-Jacques Vasseur, Jan Balzarini, Hassan B. Lazrek. Synthesis of 1,2,3-Triazolyl Nucleoside Analogs as Potential Anti-Influenza A (H3N2 Subtype) Virus Agents.. Archiv der Pharmazie / Chemistry in Life Sciences, 2014, 347 (2), pp.134-141. ⟨10.1002/ardp.201300260⟩. ⟨hal-01004380⟩