Silica lipid composite microparticles as controlled release system

Laurent Perge (1) , Coralie Guillemot (1) , Mike Robitzer (1) , Jean-Marie Devoisselle (1) , Françoise Quignard (1) , Philippe Legrand (1)

1 ICGM ICMMM - Institut Charles Gerhardt Montpellier - Institut de Chimie Moléculaire et des Matériaux de Montpellier

The present study aims to prepare new composite solid lipid microparticles (CSLM) by hot melt homogenization of a solid lipid, cetyl alcohol, at room temperature, in the presence of hydrophobic silica nanoparticles, Aerosil® R974, to replace the surfactant. Silica nanoparticles are dispersed in water in the same way as the preparation of pickering emulsions, instead of their addition in the melt lipid . We prepared unloaded CSLM or loaded with ibuprofen, a model drug to establish the role of hydrophobic silica nanoparticles on physical characteristics of microparticles, lipid and drug and on release after their incubation in PBS medium.

Domaines: Pharmacie galénique

Laurent Perge, Coralie Guillemot, Mike Robitzer, Jean-Marie Devoisselle, Françoise Quignard, et al.. Silica lipid composite microparticles as controlled release system. 7th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Mar 2010, La Valette, Malta. pp.68. ⟨hal-00912312⟩