Biological effects and equivalent doses in radiotherapy: a software solution

Cyril Voyant (1, 2) , Daniel Julian (2) , Rudy Roustit (2) , Katia Biffi (2) , Celine Lantieri Marcovici (2)

1 SPE - Sciences pour l'environnement
2 CHD Castellucio - CHD Castelluccio

The limits of TDF (time, dose, and fractionation) and linear quadratic models have been known for a long time. Medical physicists and physicians are required to provide fast and reliable interpretations regarding the delivered doses or any future prescriptions relating to treatment changes. We therefore propose a calculation interface under the GNU license to be used for equivalent doses, biological doses, and normal tumor complication probability (Lyman model). The methodology used draws from several sources: the linear-quadratic-linear model of Astrahan, the repopulation effects of Dale, and the prediction of multi-fractionated treatments of Thames. The results are obtained from an algorithm that minimizes an ad-hoc cost function, and then compared to the equivalent dose computed using standard calculators in seven French radiotherapy centers. https://github.com/cyrilvoyant/LQ-Equiv.git

Domaines: Recherche d'information [cs.IR]

Cyril Voyant, Daniel Julian, Rudy Roustit, Katia Biffi, Celine Lantieri Marcovici. Biological effects and equivalent doses in radiotherapy: a software solution. Reports of Practical Oncology & Radiotherapy, 2013. ⟨hal-00853583⟩