Acoustical method and device for determination of lipid and protein spectra of blood serum

Igor Demin , Anna Klemina , Sergey Gurbatov , Viktor Klemin

Investigation of acoustical characteristics of biological fluids for the purposes of medical diagnostics is the important problem, because of the analysis of interaction of ultrasonic waves with biomacromolecules allows to receive the unique information on their structure and properties. One of few methods, allowing to measure velocity and absorption of ultrasound in biological fluids with sufficient precision is a method of a ultrasonic interferometer of constant length or resonator method. Acoustical resonator method for determination of lipid and protein spectra of blood serum is described. This device have two ultrasonic resonator cells with volume of 80 mkl each. The cells are placed in a specially designed ultrathermostat and are operated at about 8 MHz by means of compact electronic unit. The method allows to determinate without reagents lipid components (cholesterol total, cholesterol of high and low density and triglycerides), and total protein and protein fractions in blood serum during two minutes. Traditional methods determine these components during fifteen minutes and with reagents. Comparative investigations acoustics and traditional methods shows very high correlation agreements.

Mots clés: medical acoustics; acoustical resonator; lipid and protein spectra of blood serum

Domaines: Acoustique [physics.class-ph]

Igor Demin, Anna Klemina, Sergey Gurbatov, Viktor Klemin. Acoustical method and device for determination of lipid and protein spectra of blood serum. Acoustics 2012, Apr 2012, Nantes, France. ⟨hal-00810947⟩