The effects of antioxidants on metabolic changes under conditions of noise action

Magdalina Melkonyan , Ashchen Manukyan , Susanna Karapetyan , Tatevik Meliqyan , Karine Kocharyan

The aim of the current study is to investigate the effects of endogenous antioxidant alfa-tocopherol and several bioactive compounds as preventive measures against hazardous effect of noise action on living systems. The previously obtained results testify to the noticeable decrease of the main endogenous antioxidant alfa-tocopherol content, lipid peroxidation processes activity increase both in the tissues of experimental animals under noise action and in the blood (plasma and erythrocytes) of the female employed in high noise level conditions. Correlation of changes of the studied parameters with increase of atherogenic coefficient in the blood of employees, confirms our assumption of the leading role of the disorders in pro- and antioxidant systems in the development of different pathological states, particularly atherosclerosis and heart diseases under the noise action. The introduction of alfa-tocopherolacetate has had a considerably expressed regulatory effect on the studied parameters both in experimental animals and people. Our investigations also revealed regulatory effects of several peptides, possessing adaptogenic and immunostimulating properties on the studied parameters in tissues of white rats under noise action. The results obtained testify that the functional activity of the studied peptides in certain extent depend on their effects on the pro-and antioxidant systems in tissues.

Mots clés: noise; antioxidants; lipid peroxidation; blood

Domaines: Acoustique [physics.class-ph]

Magdalina Melkonyan, Ashchen Manukyan, Susanna Karapetyan, Tatevik Meliqyan, Karine Kocharyan. The effects of antioxidants on metabolic changes under conditions of noise action. Acoustics 2012, Apr 2012, Nantes, France. ⟨hal-00810597⟩