Efficacy of anidulafungin against Aspergillus niger in vitro and in vivo

Enrique Calvo (1) , F. Javier Pastor (1) , Emilio Mayayo (1) , Josep Guarro (1)

1 CMB - Center for Microbial Biotechnology

In this study, anidulafungin (AFG) showed high in vitro activity against 10 isolates of by broth microdilution and disk diffusion methods. The efficacy of AFG at 1, 5 and 10mg/kg was tested against six of the isolates in a murine model of disseminated infection. AFG was able to reduce mortality, showing survival rates of 70-100%, 60-100% and 30-60% in mice treated with AFG at 10, 5 and 1mg/kg, respectively. AFG also showed a dose-response efficacy in reducing tissue burden in kidneys and spleen. A parallel experiment demonstrated that administration of AFG did not reduce serum concentrations of galactomannan in mice. Histopathological studies confirmed the efficacy of AFG.

Mots clés: Mice; Anidulafungin

Domaines: Microbiologie et Parasitologie

Enrique Calvo, F. Javier Pastor, Emilio Mayayo, Josep Guarro. Efficacy of anidulafungin against Aspergillus niger in vitro and in vivo. International Journal of Antimicrobial Agents, 2011, 38 (4), pp.360. ⟨10.1016/j.ijantimicag.2011.06.008⟩. ⟨hal-00725399⟩