Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model

Tobias Raupach (1) , Lars Lüthje (1) , Harald Kögler (1) , Christian Duve (1) , Frank Schweda (2) , Gerd Hasenfuss (1) , Stefan Andreas (1)

1 Department of Cardiology and Pneumology
2 Universität Regensburg

COPD with emphysema causes marked neurohumoral activation. Angiotensin II receptors are highly expressed within the lung and interfere with mechanisms involved in the progression of emphysema. This study examined the effects of an angiotensin II receptor blocker (ARB) on pulmonary and systemic manifestations of emphysema in a mouse model.

Mots clés: emphysema; animal model; angiotensin; neurohumoral activation

Domaines: Pneumologie et système respiratoire

Tobias Raupach, Lars Lüthje, Harald Kögler, Christian Duve, Frank Schweda, et al.. Local and systemic effects of angiotensin receptor blockade in an emphysema mouse model. Pulmonary Pharmacology & Therapeutics, 2011, 24 (2), pp.215. ⟨10.1016/j.pupt.2010.12.006⟩. ⟨hal-00724889⟩