Association of ex vivo vascular and bronchial dysfunctions in smokers

Mehdi Oualha (1) , Jean-François Boitiaux (1) , Jean-Marc Tadié (1) , Aurélie Cazes (2) , Marc Riquet (3) , Emmanuel Naline (4) , Dominique Israël-Biet (1, 5) , Christophe Delclaux (1, 6, 7)

1 EA 4068 - Dysfonction endothéliale et remodelage vasculaire pulmonaire dans les pathologies bronchiques obstructives
2 Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou; Département d'Anatomo-Pathologie; Paris
3 Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou; Service de Chirurgie Thoracique; Paris
4 UPRES EA 220; Pôle des maladies respiratoires; Hôpital Foch
5 Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou; Service de Pneumologie; Paris
6 Assistance Publique-Hôpitaux de Paris; Hôpital Européen Georges Pompidou; Service de Physiologie - Clinique de la Dyspnée; Paris
7 CIC Plurithématique 9201; Hôpital Européen Georges Pompidou; Paris

It has recently been shown that systemic endothelial dysfunction is associated with airflow limitation in COPD. We conducted this ex vivo study to assess whether endothelial dysfunction of pulmonary arteries of former smokers was associated with modifications of airway functions.

Mots clés: zaprinast; acetylcholine; bronchial ring; arterial ring; endothelial dysfunction

Domaines: Pneumologie et système respiratoire

Mehdi Oualha, Jean-François Boitiaux, Jean-Marc Tadié, Aurélie Cazes, Marc Riquet, et al.. Association of ex vivo vascular and bronchial dysfunctions in smokers. Pulmonary Pharmacology & Therapeutics, 2011, 24 (2), pp.227. ⟨10.1016/j.pupt.2010.12.004⟩. ⟨hal-00724888⟩